Research & News
The latest discoveries, clinical studies, and news advancing our understanding of KCNMA1 Channelopathy — and bringing us closer to better treatments.
Key Milestones
Significant findings and developments from the KCNMA1 research community.
Active Research Areas
Scientists around the world are working on multiple fronts to understand and treat KCNMA1 Channelopathy.
BK Channel Biophysics
Understanding how GOF and LOF mutations alter BK channel gating, conductance, and interaction with voltage and calcium — the molecular foundation for all downstream research.
Animal Models & CRISPR
Transgenic and CRISPR-edited mouse lines carrying patient-matched variants allow researchers to study how specific mutations produce seizures, dyskinesia, and other symptoms in a controlled system.
Pharmacological Approaches
Identifying existing and novel drugs that modulate BK channel activity — including stimulants for GOF variants and potential BK activators for LOF variants.
Natural History & Patient Registry
Collecting longitudinal data from patients worldwide to characterize the full clinical spectrum, identify genotype-phenotype correlations, and support future clinical trials.
Help advance the research — join the patient registry
The KCIAF / CORDs Patient Registry is one of the most powerful tools researchers have. Every enrolled patient adds to our collective understanding of KCNMA1 Channelopathy and helps make future clinical trials possible.
Enroll in the registry